JN Beauty Solutions™

Tranexamic Acid is a water-soluble synthetic derivative derived from the amino acid Lysine. In medical specialties, this is a substance that helps blood clot with the effect of inhibiting the activation of plasminogen to plasmin. A molecule that plays an important role in breaking down fibrin, the basic component of blood clots during the hemostasis process.

Tranexamic acid was discovered and published by scientists in 1962, they are on the list of the most effective and safe drugs today. In particular, Tranexamic acid is considered a drug on the list of essential drugs of the World Health Organization WHO.

In 1979, doctors noted that patients treated with Tranexamic Acid to stop bleeding had a marked improvement in skin color. Since then, Tranexamic Acid has also been widely used in cosmetics to nourish the skin and treat melasma in many different forms of extracts such as Tranexamic Acid or M-Tranexamic Acid.

Basically, Tranexamic acid can help solve the three most stubborn skin care problems namely pigmentation, melasma, and age spots:

  • Treatment of melasma, tanning, freckles, sunburn, melasma occurs due to hormonal disturbances during pregnancy of pregnant women.
  • Visibly supports the blurring of post-acne scars, reducing the formation of acne scars
  • Prevent accumulation of melanin pigment, brighten skin
  • Anti-allergic, skin irritation, reduce redness
  • Anti-inflammatory, anti-inflammatory.
  • Reduces capillary proliferation arising during pigmentation treatment.
  • Soothe the skin, limit skin irritation, and better support the treatment of melasma.
  • Restores pigmentation and skin layers damaged by ultraviolet rays.

In a trial conducted with 28 patients with melasma and 5 patients with freckles, Tranexamic Acid for 5-18 weeks helped 80% of women with melasma and 75% of women with freckles, brown spots are visibly improved, and the skin is brighter and more even.

When compared with other skincare ingredients such as Azelaic Acid, L-Ascorbic Acid, Arbutin… Tranexamic acid shows superior effectiveness in multi-function such as anti-inflammatory, reducing dark spots, anti-irritation, and more stable when exposed to light, and high temperature.

The effectiveness of Tranexamic acid in treating melasma is comparable to that of hydroquinone (a substance that lightens the skin) without the side effects of hydroquinone. Nearly 96% of study participants using Tranexamic Acid noticed an improvement in melasma and discoloration problems after 12 weeks of daily use when combined with sun protection.

Side effects of Tranexamic Acid:

Although Tranexamic acid is benign for most skin types, people with super sensitive skin or eczema should test before using it.

Tranexamic acid eliminates melasma by blocking the interaction between keratinocytes (aka skin cells) and melanocytes (also called melanin-producing cells) to inhibit melanin synthesis, the leading cause of dark spots and discoloration on the skin’s surface.

At the same time, it helps to reduce the number of weak cells on the skin, thereby helping the skin reduce inflammation, fight inflammation, reduce itching and reduce irritation if any. Besides, it also has the ability to slow down melanin production by tyrosinase (as a competitive antagonist) because of its similar structure to tyrosine.

In theory, tranexamic acid could be included in almost anyone’s skincare routine. Unlike other acid ingredients, Tranexamic Acid does not provide exfoliating or collagen-stimulating benefits and should be reserved for those who want to improve their hyperpigmentation as in Asia and Vietnam, generally Melasma or pigment disorder.

Kilgore, a leading dermatologist says, “If you have a lot of dark spots, apply a product with Tranexamic Acid all over your face during the day after cleansing, toning, and using an AHA exfoliant or BHA. Follow with serum or any other treatment product, and finish with your sun protection. You can use it topically during the day, apply it to darkened areas, and finish with sun protection. You can follow the same routine for the night, followed by the other treatments at night and then the moisturizer.”

Kilgore also emphasizes that to successfully fade hyper_pigmentation, consistent use of the product is crucial. “Most people will notice results with regular use in 8-12 weeks. Research has shown that Tranexamic Acid is safe when applied to the skin daily for several months,” she explains.

With topical concentrations of 2-5% usually showing results after two to three months of once or twice daily use.” One thing to keep in mind, however, is that Tranexamic Acid is a water-soluble ingredient, which means it should be used in conjunction with oil-soluble products like oil-based moisturizers – especially if you have dry skin. The addition of emollients can prevent the skin from drying out due to the effects of acids, resulting in a healthy and more balanced skin barrier.

“Tranexamic acid shows promising results when used to reduce unwanted hyperpigmentation,” says Dr. Deborah Lee.

Hyperpigmentation is a common problem in skin care and topical use of tranexamic acid has, until recently, not been recognized as a potential treatment. Tranexamic acid has recently gained popularity due to Instagram, the impact of various influencers, and the opinions of several Consultant dermatologists. It has been described as a “hero ingredient” due to its potent skin properties. And Dr. David Lim says it’s ‘one of the biggest breakthroughs in the treatment of pigmentation, especially melasma’.

“Tranexamic Acid, a derivative of the amino acid lysine, is currently one of the best after pigment actives for improving the appearance of blemishes,” says Joanne Healy, Product Development Manager at Advanced Skin Technology.

Dark spots and uneven hyperpigmentation. It acts as necessary support for sunscreen to soothe, condition, and protect skin from future environmental damage. Tranexamic has a unique method of action that not only fades dark spots but also has a significant soothing effect. It has a double response on 2 key aspects of light effects, minimizing both redness and hyperpigmentation. “

There is an article in Beauty Magazine that also noted the anti-inflammatory effects of Tranexamic Acid. It’s also an acid that doesn’t work like the other acids we’re all familiar with in things like chemical exfoliation and peels. It doesn’t work that way. Experts have proven that “Unlike other acids such as glycolic acid and salicylic acid, tranexamic acid does not actually exfoliate the skin, instead, tranexamic acid is a potent anti-inflammatory that disrupts the skin. The overproduction of melanin is caused by an exacerbation of skin inflammation. Melanin is the natural pigment that gives your skin its color, and although melanin helps protect the skin, when overproduced it can cause dark patches, dark spots, and dullness.”

It can be said that Tranexamic acid is a versatile ingredient that helps to fade, reduce pigmentation and dark spots, reduce and prevent the formation of acne scars and brown spots caused by sun exposure.

After only 6-8 weeks of continuous use, you will see a significant improvement in properly improved skin. If combined with a professional melasma cream or serum of JN Beauty Solutions such as Diamond Bright Pigment Night Gel / Diamond Bright Night Cream, the effect is doubled, just 2-4 weeks.

Tranexamic Acid currently on the market is combined by laboratories with a number of ingredients to support effective treatment of dark spots, pigmentation, and skin lightening. The ingredients can be listed as vitamin C, vitamin C derivatives such as L-cysteine, Ascorbic Acid, L-Ascorbic… These substances will support Tranexamic Acid to penetrate deeper into the skin, helping the skin absorb better, especially the dark skin. However, when combined with Alpha Arbutin, one of the safest and most expensive skin lightening and anti-pigmentation ingredients, the effect is more pronounced.

Let’s learn a little about Alpha Arbutin:

Arbutin is a familiar skin whitening ingredient in most high-end cosmetic lines. Chemically, Arbutin is a form of Hydroquinone (a skin whitening agent) but its molecule contains glucose. It is this Glucose that is what determines how Hydroquinone and Arbutin work differently and has been approved by the FDA. Instead of killing Melanocytes, Arbutin helps inhibit the enzyme that produces melanin in the cells. Because of how it works differently, Arbutin is a more benign skin whitening agent and does not have the same unwanted side effects as Hydroquinone, although the results may be slower.

Arbutin exists in two forms, alpha, and beta. The alpha form is more stable and has a stronger inhibitory effect than the beta form. In nature, Alpha-Arbutin is extracted from the bearberry tree, a plant that grows in most of the Northern and Southern regions of America. In addition, Alpha-Arbutin is also found in wheat germ, pear skin, and leaves of blueberries. However, it is very difficult to extract arbutin from nature, so there are currently quite a few synthetic arbutin in the laboratory. However, reputable and quality brands do not hesitate to invest in natural Alpha Arbutin extract because Alpha-Arbutin is 10 times more effective than other forms of Arbutin.

Alpha Arbutin’s Mechanism of Action

Alpha Arbutin acts through a controlled release that inhibits the oxidation of L-tyrosine (mycophenolate activity) catalyzed by tyrosinase and counteracts tyrosinase binding activity. Thanks to the molecule that has more Glucose, instead of killing Melanocytes, Arbutin helps inhibit the enzymes that produce melanin in the cells to bring the skin whitening effect, raise the desired skin tone, and have no side effects unwelcome like hydroquinone.

Also, because the release of glucoside hydrolysate is slow, Arbutin is, therefore, less irritating than Hydroquinones (skin whitening agents) directly and has no unwanted side effects, although the results are slow and steady, the effect is firmer and does not harm the skin.

Researchers have been studying Arbutin’s ability to inhibit tyrosinase in skin cells, since the 1990s. There is promising scientific evidence that it is effective as a skin lightener, especially as a skin lightener. related to synthetic forms such as Alpha-Arbutin and Deoxyarbutin. However, most of this evidence is from animal studies or in vitro studies on cultured human skin cells.

Benefits of Arbutin for skin

It is not simply that most skincare and beauty products have Arbutin. Arbutin is truly a beauty elixir.

  • Arbutin helps to decrease pigmentation, and reduce the degree of tanning after UV exposure, especially in sun-exposed skin by the strong activity of Melanocytes.
  • Even skin tone, quickly remove brown spots accumulated on the skin for a long time.
  • Anti-aging, prevent free radicals and rejuvenate the skin.
  • The best choice of Melasma skin, Freckles: Freckles are caused by concentrated clusters of melanin, which are formed and color intensity can be activated by regular exposure to UVB rays, which stimulates melanin production by melanocytes. Alpha-Arbutin inhibits Melanocyte activity and aids in the depletion of melanin in the Keratogenous layer.

According to studies, using Arbutin at a concentration of 1% or more will show visible results and is best combined with other whitening agents such as Kojic Acid. Products containing Alpha-arbutin provide the best results after use for at least 2-3 months.

The special feature of Alpha Arbutin that people love widely is its benignity. Currently, there is no research that shows with certainty that when taking Alpha Arbutin in large amounts and long-term can harm the skin. Most of the concentrations in cosmetics are very well controlled, are at a moderate level, can maximize their use, and are safe. If you want to find a skin whitening product that is suitable for your skin, without any side effects, then Alpha Arbutin is a wise choice.

When we combined Alpha Arbutin and Tranexamic Acid into the JN Beauty Solutions™ Brilliance Essence Serum, we are driving consumers toward a safer and more sustainable treatment for melasma and pigmentation problems. In addition to brightening, inhibiting, and reducing inflammation… we also aim to rebuild a clean and healthy skin foundation for consumers.

The launch of JN Beauty Solutions™ Brilliance Essence in 2022 welcomes the new year and marks two years of the outstanding success of JN Beauty Solutions™ in providing professional and quality skin care products.

The product has been practically tested for more than 15 months before the official launch, 100% made in the US. It is committed to bringing consumers the benefits of outstanding efficiency and safety.

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